Furthermore, univariate Kaplan-Meier/log-rank analysis revealed that decreased biochemical recurrence-free survival was noted in PCa cases with positive expression of MT-2A and cyclin E as well as negative expression of E-cadherin (P=0.022, 0.028 and 0.011 log rank test, respectively) (Fig. 2). The gene discussed is CCNE1; the disease is posterior cortical atrophy.