Based on the results of univariate analysis, the positive expression of MT-2A (HR=2.15; 95% CI=1.14–3.08; P=0.009) and cyclin E (HR=1.45; 95% CI=1.02–1.92; P=0.037) as well as the negative expression of E-cadherin (HR=1.31; 95% CI=1.03–2.21; P=0.047) were indicated to be significant prognostic factors for the biochemical recurrence of PCa (Table II). Here, CCNE1 is linked to posterior cortical atrophy.