According to multivariate Cox regression analysis, MT-2A expression (HR=2.01; 95% CI=1.08–3.15; P=0.015), E-cadherin expression (HR=1.79; 95% CI=1.08–2.21; P=0.042) and cyclin E expression (HR=1.92; 95% CI=1.22–2.45; P=0.020) were demonstrated to be independent predictors for biochemical recurrence of PCa (Table II). This evidence concerns the gene CDH1 and posterior cortical atrophy.