The rate of KAI1 mRNA expression in the superior differentiation group, which consisted of well- and moderately-differentiated adenocarcinoma, was increased compared with the expression in the inferior differentiation group, which consisted of poorly-differentiated and mucinous adenocarcinoma and signet-ring cell carcinoma (P<0.05). This evidence concerns the gene CD82 and colon mucinous adenocarcinoma.