FLT4 and metastatic malignant neoplasm in the lymph nodes: In conclusion, although the association between lymphangiogenesis and lymph node metastasis is controversial, determining the status of VEGF-C/VEGFR-3 expression may help predict which patients are at risk of developing regional recurrence and provide a novel target for the treatment of OTSCC through the suppression of lymph node metastasis.