PTPR have morphological features in common with a number of other papillary-like tumors that occur in the pineal region, including pineal parenchymal neoplasms, choroid plexus papilloma, papillary ependymoma, metastatic papillary carcinomas, papillary meningioma and germ cell tumors (5,7), which complicates the clinical diagnosis of PTPR. This evidence concerns the gene PTPRR and pineal parenchymal cell neoplasm.