It is quite astonishing that DSCAM-AS1, originally described by Liu and coworkers [32], has escaped the attention of many studies that have addressed lncRNA expression in breast cancer, especially due to the fact that, among all transcripts (protein coding and non-coding) DSCAM-AS1 classifies as the eighth most abundant RNA in luminal breast cancer cell lines (the first considering only lncRNA genes) and that it is neatly associated to ER-positivity. The gene discussed is DSCAM; the disease is breast carcinoma.