ESR1 and neoplasm: First, it had the highest value of RPKM among differentially expressed lncRNAs in MCF-7 (RPKM = 394 in siCTR condition, Supplemental Table 1A); second, it is characterized by the widest differential range of gene expression between luminal and non-luminal cell lines (log2 fold change = 9.91) and, third, it showed significant correlation with ERα expression in both cell lines and tumor samples (see above).