A series of studies performed using glioma [22], gastric cancer [23, 24], and lung cancer cells [25, 44] showed that Bcl-w overexpression stimulates the invasion pathway involving Src, epidermal growth factor receptor (EGFR), phosphoinositide 3-kinase (PI3K), Akt, Sp1, matrix metalloproteinase (MMP)-2, urokinase-type plasminogen activator (uPA), and focal adhesion kinase (FAK). Here, MMP2 is linked to central nervous system cancer.