The induction of MMP-2 and/or MMP-9 by Bcl-2 overexpression is mediated by AP-1 in lung cancer cells [17], furin and TGF-β in glioma cells [13], and the N-cadherin/FGF receptor/ERK pathway in squamous carcinoma cells [16]. The gene discussed is MMP9; the disease is glioma.