A direct correlation exists between elevated COX-2/PGE2, 5LO/LTB4, and the pathogenesis of colorectal, prostate, lung and breast cancers, as well as several hematological malignancies including chronic lymphocytic leukemia, Hodgkin's and non-Hodgkin's lymphomas, and multiple myeloma [29–32]. This evidence concerns the gene PTGS2 and B-cell chronic lymphocytic leukemia.