CD8A and lung carcinoma: After immunization of A2-5/Th/CpG/ISA twice in HLA-A2 transgenic mice, A2-5-induced CTLs destroyed lung cancer H2981 cells (28.5 ± 1.78%) and this specific cytotoxicity was inhibited with either anti-HLA-A2 (9.0 ± 0.74%) or anti-CD8 (10.0 ± 0.86%) monoclonal antibodies in vitro (Figure 4A).