Multiple independent genome-wide association studies (GWAS) have shown that SNPs in the TERT-CLPTM1L locus were significantly associated with the risk of many different types of cancer, including basal cell carcinoma, glioma, lung, cervical, prostate, bladder, pancreatic, chronic lymphocytic leukemia, and testicular germ cell cancers [10–17]. The gene discussed is CLPTM1L; the disease is cancer.