ITCH and familial pancreatic carcinoma: Furthermore, the patient cohort with relatively higher ITCH expression had a significantly less overall survival (P = 0.036) (Figure 1C) and a significantly higher percent progression (P = 0.0039) compared to the cohort with relatively lower ITCH expression (Figure 1D), cumulatively reinforcing that ITCH expression is upregulated in metastatic pancreatic cancer and might be useful as a diagnostic and prognostic marker for pancreatic cancer.