Recently, numerous genome-wide association studies have been published for AD, and many AD susceptibility loci have been identified, such as APOE, LRAT, APOC1, SORL1, GAB2, PGBD1, CHRNB2, CLU, PICALM, CR1, PCDH11X and TRPC4AP [7-17]. Here, CLU is linked to Alzheimer disease.