The TERT-CLPTM1L locus has been identified in multiple cancer susceptibility GWAS51, 52, 53, 54, 55, 56, 57, 58 and it is of interest that the CRC SNP rs2736100 also shows signs of significance in EC in our analysis (OR:1.08, 95%CI:1.04-1.12, P = 1.67 × 10−4). The gene discussed is TERT; the disease is colorectal carcinoma.