In model 2, overweight (beta = −338.718, 95% CI = −552.786 ~ −124.651, p < 0.01), obesity (beta = −530.275, 95% CI = −832.967 ~ −227.583, p < 0.01), and current smoking (beta = −654.353, 95% CI = −654.353 ~ −100.397, p < 0.01) were negatively associated with cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. This evidence concerns the gene CTF1 and obesity due to melanocortin 4 receptor deficiency.