To employ DR5 up-regulation as the strategy of to overcome TRAIL resistance,Tse et al. identified cryptotanshinone, amongtanshinone I, dihydrotanshione I, and tanshinone IIA, as the most potenttanshinones to induce DR5 expression in the TRAILresistant human melanoma A375cells [58]. The gene discussed is TNFSF10; the disease is melanoma.