Later on, Tse et al. identified crytotanshinone as a TRAIL sensitizerin the human melanoma cell line A375 and the lung adenocarcinoma cell line A549,both refractory to TRAIL [58].Likewise, Shin et al. recently reported thattanshinone I restores the sensitivity of the TRAIL-resistant human prostate cancercell lines PC-3 and DU145 to TRAIL-induced apoptosis [59]. The gene discussed is TNFSF10; the disease is lung adenocarcinoma.