To employ DR5 up-regulation as the strategy of to overcome TRAIL resistance,Tse et al. identified cryptotanshinone, amongtanshinone I, dihydrotanshione I, and tanshinone IIA, as the most potenttanshinones to induce DR5 expression in the TRAILresistant human melanoma A375cells [58]. This evidence concerns the gene TNFRSF10B and melanoma.