Although a role for NEET proteins in Fe-S biogenesis has been previously proposed (Ferecatu et al., 2014), and although it is tempting to speculate that NAF-1 deficiency is directly responsible for the changes in Fe ion and ROS homeostasis in cancer cells through this proposed role (that our results, described above, support), further studies are required to support this notion. Here, NAF1 is linked to cancer.