GRIA2 and hereditary spastic paraplegia: These results indicate that HSP is expressed by GluA2-containing AMPARs under normal conditions, whereas both GluA2-containing and GluA2-lacking AMPARs contribute to HSP under the condition of miR124 overexpression (Supplementary Fig. 10 and Supplementary Table 2, 12 h TTX/APV control=1.22±0.05 of basal control, n=6, P<0.01; 12 h TTX/APV miR124=1.38±0.05, n=6, P<0.001; 12 h TTX/APV control+PhTx=1.14±0.04, n=9, P<0.05; 12 h TTX/APV miR124+PhTx=1.19±0.04, n=9, P<0.01; t-test).