Tumor differentiation (hazard ratio [HR] 0.404, 95% CI 0.203–0.792, P = 0.008), AFP (HR 0.134, 95% CI 0.029–0.616, P = 0.01) and administration approach to NAC (HR 2.148, 95% CI 1.138–4.053, P = 0.018) were found to be significantly associated pathological response. Here, AFP is linked to neoplasm.