Yoshida et al. reported that sublethal heat treatment skews HCC cells toward EMT and transforms them to a progenitor-like, highly proliferative cellular phenotype in vitro and in vivo, which driven significantly by p46Shc-ERK1/2, and suboptimal RFA accelerates HCC growth and spread by transiently inducing an EMT-like, more aggressive cellular phenotype [12]. Here, MAPK3 is linked to hepatocellular carcinoma.