While our findings focus on the role of PTPRN2 and PLCβ1‐mediated depletion of PI(4,5)P2 on actin dynamics and migration, they do not exclude the impact of altered levels of this lipid on additional cellular processes, which may also contribute to metastatic phenotypes through either cancer cell‐intrinsic or cancer cell‐extrinsic events (Tlsty & Coussens, 2006; Lu et al, 2012). This evidence concerns the gene PTPRN2 and cancer.