Increased cofilin expression has previously been implicated in breast cancer progression, as well as in oral squamous cellular carcinoma, renal cell carcinoma, and ovarian cancer progression (Martoglio et al, 2000; Unwin et al, 2003; Wang et al, 2004, 2007; Turhani et al, 2006). Here, CFL1 is linked to renal cell carcinoma.