The XPO-1 levels were statistically lower in androgen dependent (LAPC-4, CWR22, LnCaP, LnCaP-104S, DuCaP, VCaP, PC3AR and DU145AR) when compared to those observed in androgen independent/CRPC (LnCaP-104R1, LnCaP-C81, C4-2B, 22rv1, PC3 and PC3 variants [PC3PTEN, PC3M-pro4, PC3M-Ln4, PC3Me, PCb2] and DU145) PCa cell lines (1.41 ± 0.47 vs 2.44 ± 0.52, P = 0.0150, Fig. 1g) The comparison in PC3 cell derivatives showed higher XPO-1 levels in more aggressive/metastatic cells. This evidence concerns the gene XPO1 and posterior cortical atrophy.