In this study, we show that XPO-1 inhibition using SINE compounds: KPT-185, KPT-205, KPT-225, and KPT-127 reduced, in a panel of PCa cells, XPO-1-dependent nuclear export of different proteins including AR, Foxo3a, and survivin, modulating cell cycle progression through both a G1 and a G2/M-arrest followed by apoptosis. Here, AR is linked to posterior cortical atrophy.