NR1H4 and metabolic dysfunction-associated steatotic liver disease: In our previous study, we found that the antiparasitic drug ivermectin can target mammalian FXR to regulate cholesterol and glucose metabolism, which make us wonder whether this unique antiparasitic FXR ligand has therapeutic effects on NAFLD by regulating lipid metabolism, and whether other macrocyclic lactone analogues have similar effects on metabolism.