A PDGFB binding DNA aptamer (AX102) has been generated which inhibits PDGFB-PDGFRβ interactions; this aptamer could cause pericyte loss and vascular regression in syngeneic mouse tumour models, although this did not affect overall tumour growth it provided a strategy that could be used in combination with other anti-angiogenics [24]. Here, PDGFRB is linked to neoplasm.