EPHB4 and pancreatic neoplasm: The most promising approach inhibiting this interaction so far involves a soluble EphB4 ECD conjugated to human serum albumin (EphB4-ECD-HSA), this has shown anti-angiogenic effects on pancreatic tumours in Rip1-Tag2 mice, which could be improved with Dll4-Notch blockade using Dll4-ECD-Fc [95].