EPHA2 and neoplasm: The use of EphA2-ECD-Fc has been shown to reduce tumour angiogenesis in vivo in Rip1Tag2 pancreatic and 4T1 breast tumour models; it also had inhibitory effects on bovine microvascular cells in vitro but not on the 4T1 tumour cells in culture demonstrating vasculature specific effects [90].