In the present study, the expression of Slc10a1 and Slco1a1 was increased in LD-fed Elovl6−/−Ldlr−/− mice in concert with decreased expression of Abcc1 and Abcc4. In support of these observations, increases in serum BAs were related to a decrease and an increase in Slco1a1 and Abcc4 expression, respectively, in the livers of mouse NASH models39. This evidence concerns the gene ABCC4 and metabolic dysfunction-associated steatohepatitis.