Neoplastic remodeling of the ECM by modulating stromal cell secretion of macromolecules, such as Versican, is a well-recognized phenomenon and may be one mechanism by which tumor cells control their microenvironment to facilitate local invasion and metastasis.12, 13, 16, 22, 23 Considering the correlation of high Versican expression with tumor metastasis and recurrence found in our study, Versican may promote tumor progression by prompting tumor invasion. Here, VCAN is linked to neoplasm.