APC and colorectal cancer: In certain colorectal cancers, there is a probability of finding an exclusive catenin (cadherin-associated protein) beta 1 mutation when APC mutations are lacking.53, 54 This was also supported by the conclusive evidence, which came from the studies of Mirabelli-Primadehl et al.55 regarding the role of β-catenin mutations in colorectal cancers.