This drug was investigated to check its inhibitory role in regulating BMI1 expression both in protein and transcript levels in nasopharyngeal carcinoma cells.132 To date, no small molecules have been reported to inhibit BMI1 with competent specificities, although experimental evidences cited above using HDAC inhibitors and artemisinin bring a rationale to develop more agents for therapeutic targeting of BMI 1. This evidence concerns the gene BMI1 and nasopharyngeal carcinoma.