BMI1 and Familial prostate cancer: Prostate cancer cells too have a heightened expression of BMI1 in tumors with Gleason scores of 8 or higher.90 Glinsky and colleagues91 carried out a microarray analysis in 11 different types of cancer specimens and indicated that the conserved BMI1 driven pathway is engaged in a metastatic behavior of human malignancies along with a stem cell-like expression profile ultimately leading to disease recurrence after therapy.