Notch signaling also has an oncogenic role in T-ALL where Notch 1 was identified to be involved in t (7; 9)(q34;q34.3) chromosomal translocation to bring out the disease outcome.37 Subsequent studies have brought newer insights to the role of Notch in human T-ALLs, with discovery of two types activating mutations within Notch 1.38 One mutation was in the extracellular hetero-dimerization domain, a change in the amino-acid sequence leading to ligand-independent metalloproteinase cleavage site S2, whereas the second involved Notch 1 proline, glutamic acid, serine, threonine sequence domain. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.