APC and colorectal cancer: The relevance of Wnt signaling in human cancers was perhaps best well known for its role in colon cancer where the healthy colonic epithelia accumulates mutation in specific genes such as APC, β-catenin, K-ras and p53.51 Morin PJ et al.52 had carried out genetic studies in four different kinds of APC mutants and analyzed that the presence of APC mutations in colorectal cancer also leads to defective downregulation of β-catenin and Tcf-4 transcriptional activity.