SHH and neoplasm: Downregulation of Gli1 is mediated by miR-324-5p, and subsequent loss of miR-324-5p have led to neoplastic transformation into medulloblastoma.24 Ptc and Gli1 proteins were seen to be highly expressed in ovarian cancer patients as reported by Liao et al.25 The authors in this study also observed that there was a significant overexpression of SHh mRNA in the patient's tumor tissues.