SHH and cancer: It can also be acetylated, ubiquitinated and sumoylated.6, 26, 27, 28 Several posttranslational modifications potentially interrupt the Gli1–Sufu interactions and release Gli1 from the inhibition by Sufu.22, 26 Gli1 modification enzymes such as histone deacetylases and atypical protein kinase C (aPKC) family members ι and λ are promising targets for the treatment of Shh-related cancers.28, 29