HCK and neoplasm: In mammals, there are 10 families of nonreceptor tyrosine kinases.30, 31 The Src family, consisting of Src, Hck, Lyn, Fyn, Fgr, Blk, Lck, Yes and Ylk, play essential roles in malignant transformation and tumor progression.32, 33 Besides the kinase activities, Src family kinases also display kinase activity-independent functions,34, 35 mostly through protein-protein interactions.