SHH and medulloblastoma: Interestingly, both mRNA and protein levels of Hck were significantly higher in medulloblastoma compared with normal cerebellum and NIH3T3 cells (Figures 6c and d, Supplementary Figure S5), which may contribute to the abnormally high Shh/Gli1 activities in Shh-type medulloblastoma and the uncontrolled proliferation of these cells.