For example, the mutated genes common in all tumor regions from PtA, BCL6B,20 MYH11,21 SUFU22 act as tumor suppressor genes, and mutations in BCL6B (Indel), MYH11(M816K) and SUFU(Y90S) could inactivate the gene function and contribute to tumorigenesis. The gene discussed is SUFU; the disease is neoplasm.