In PtA (circle III in Figure 4a), all tumor regions shared four common actionable mutated genes (MTFHR, MYH11, ABCC4 and GPRC6A); in PtB (circle III in Figure 4b), all tumor regions, including the metastasis, shared five druggable mutated genes (TP53, GPR37, HGF, CENPE and HTR3D). Here, TP53 is linked to neoplasm.