INS and obesity due to melanocortin 4 receptor deficiency: The HMW complex is the most active form, and it plays a role in improving insulin sensitivity and protecting against the development of type 2 diabetes (T2D).2 The serum levels of adiponectin are negatively correlated with obesity and T2D, and impaired adiponectin multimerization, particularly the selective reduction of HMW complexes, is associated with obesity, insulin resistance, T2D and atherosclerosis.2