Thus, this study aimed to assess the regulation of adiponectin secretion and multimerization during the fasting and postprandial stages in rats fed control diet (CD) or HFD containing different types of dietary fat (coconut, safflower or soybean oil) with distinct proportions of saturated, monounsaturated and polyunsaturated fatty acids for 21 days, before the onset of obesity to avoid the influence of biochemical abnormalities that occur as a consequence of hypertrophic adipose tissue. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.