IFNG and infection: A possible rapprochement between these different plausible effects is that at tissue level, IL-10 tightly controls the immune response to minimise tissue damage, while at the peripheral level, both IFN-γ and IL-10 could have a protective role, since IFN-γ is associated with a strong host cell mediated immune response and IL-10 allows for disease resistance and decreased likelihood of infection [7, 20].