DRD3 and Anxiety: Interestingly, in contrast to the male-specific effect on anxiety shown in Figs 1 and 2, the preadolescent stress-induced changes in latency to immobility and total immobility (p = 0.004, U = 3.0, Mann-Whitney Rank Sum test and p = 0.003, Student’s t-test, respectively) were also observed in adult female drd3-EGFP mice subjected to the preadolescent restraint stress and social isolation treatment (Fig 6C and 6D).