The depression-related behaviors observed in the adult mice that were subjected to repetitive restraint stress during preadolescence and social isolation were prevented if the preadolescent drd3-EGFP mice were systemically administered 10 mg/kg SB277011-A, a D3 receptor-selective antagonist, 10 minutes before each restraint stress episode during the P35-P39 preadolescent period (Fig 8A and 8B). The gene discussed is DRD3; the disease is major depressive disorder.