In WT mice, treatment with the cholecystokinin analog caerulein leads to pancreatitis [28, 29] concomitant with the activation of the type I interferon signaling (S2 Fig) To address the consequences of interferon signaling disruption during the inflammation and regeneration process we treated mice with caerulein to induce a pancreatitis in WT and Ifnardel mice [30]. This evidence concerns the gene CCK and pancreatitis.