We further showed that the DEG signatures from HOPX and GATA6 double-knockdown in the lung adenocarcinoma cell lines[59] and GPR116 knockdown in the murine type II alveolar epithelial cells from the Gpr116 knockout mice (GSE41417)[62] were significantly enriched in HOPX and Gpr116’s neighborhoods, respectively, (see S9 Fig). The gene discussed is ADGRF5; the disease is lung adenocarcinoma.