There are 14 multiscale hub genes including ROPN1, TPX2, TEKT1, FOXA1, ESR1, CCNT1, SDPR, THSD4, MLPH, TBC1D9, FOXC1, SPDEF, SFRP1, and AR. Many of these genes are known to play important roles in breast cancer etiology. Here, SPDEF is linked to breast cancer.