JAG1 and Alagille syndrome: Since craniofacial dysmorfia and embryotoxon posterior are difficult to find in newborns or patients in early infancy and liver histology may be inconclusive, we suggest that patients with neonatal cholestasis due to biliary atresia and either systolic murmur or any single clinical feature characteristic for Alagille syndrome should be elicited for mutational analysis of JAG1 before surgery.