TNF and squamous cell carcinoma: Comparably, an enhanced secretion of IL-6 and IL-8 was observed in a three-dimensional human tissue model based on TR146 cells isolated from a squamous cell carcinoma of the buccal mucosa [27], while an and inhibiting effect on the release of IL-5, interferon (INF)-γ, and tumor necrosis factor (TNF)-α was reported in human peripheral blood mononuclear cells (PBMC) obtained from healthy male volunteers [28].