This result contrasts starkly with the fact that IFN-I signals on corneal resident cells play an important role in recruiting CD11b+Ly-6Chi monocytes in the corneal area [13], but is in line with a report that IFN-I signaling on the hematopoietic cell lineage plays a dominant role in leukocyte recruitment into inflammatory lung tissues after influenza infection [29]. This evidence concerns the gene ITGAM and influenza.