CCL2 and infection: In addition, since our preliminary data showed that expression of the chemokine CCL2, a major factor in monocyte recruitment, was early and markedly enhanced in the vaginal tract of WT BL/6 mice upon mucosal HSV-1 infection (S2 Fig), we performed kinetic examinations of recruited myeloid-derived leukocyte subpopulations in the vaginal tract and its draining LN (iliac LN) 12, 24, 48, and 72 h after infection.