Thus, CD4+ T cells may also mediate upregulated expression of angiostatic chemokines such as CXCL9, CXCL10, and CXCL14 that are capable of inhibiting tumor growth (reviewed in [40]) or may downregulate expression of the chemokine receptor CXCR2 or its many ligands that promote angiogenesis (reviewed in [43, 44]). This evidence concerns the gene CD4 and neoplasm.