When stratified by cancer stage, the association between SALP levels and prognosis among osteosarcoma patients seemed to be strengthened in the subgroup of metastatic patients (Enneking stage III), with HRs of OS and EFS being 2.67 (95% CI: 1.75–4.06; Z = 4.56; p = 0.400) and 2.77 (95% CI: 1.88–4.09; Z = 5.13; p = 0.906), respectively, while in the subgroup of localized osteosarcoma patients (Enneking stage II), the HRs of OS and EFS were 1.75 (95% CI: 1.42–2.15; Z = 5.29;  p = 0.740) and 1.88 (95% CI: 1.29–2.73; Z = 3.31; p = 0.386), respectively. Here, KHDRBS3 is linked to cancer.