Takasato et al. were able to generate UB and MM between 14 and 18 days, whereas Lam et al generated SIX2+ SALL1+ WT1+ cap mesenchyme by 8 days and showed the potency of PAX2+ LHX1+ imtermediate mesodermal cells to generate tubule structures that express Lotus lectin and Ksp-Cadherin after 9 days of differentiation (Lam et al., 2014; Takasato et al., 2014). This evidence concerns the gene LHX1 and Miyoshi myopathy.