For example, based on cBioPortal, mutations at the codon 248 of p53 are most prevalently observed in human pancreatic tumors, whereas in breast tumors, codons 275 and 175 are most frequently mutated, respectively (5, 6), further suggesting that different p53 mutations impart unique activities to drive development of different tumor types. The gene discussed is TP53; the disease is breast neoplasm.