TARDBP and amyotrophic lateral sclerosis: Treatment with methylene blue, an aggregation inhibitor of the phenothiazine class, not only rescued toxic phenotypes (including neuronal dysfunction and oxidative stress) associated with mutant TDP-43 and FUS in C. elegans and zebrafish ALS models [62], but also ameliorated Tau mediated toxicity in a newly established C. elegans model [36].