CYGB and lung cancer: In detail, Oleksiewicz et al. showed (1) marked down-regulation of Cygb protein in human lung cancer cell line compared to normal human epithelial cell lines and possible involvement of promoter methylation and (2) significantly reduced Cygb mRNA expression in non-small cell lung cancer tissues compared with normal lung tissue (Mann-Whitney test, P = 2.3 × 10−7), suggesting the possible tumor suppressor function of Cygb (Oleksiewicz et al., 2013).