Although still under debate if hyperactivated PKA or CaMKII play the major role for increased RyR2 activation and subsequent SR Ca2+ leak, it is common sense that β-adrenoceptor stimulation is the general trigger for SR Ca2+ leak in both atrial and ventricular arrhythmias (Eisner et al., 2009; Eschenhagen, 2010; Dobrev et al., 2011). This evidence concerns the gene RYR2 and Ventricular arrhythmia.