Accordingly, there was an apoA-I gene dosage effect on Lewis lung tumor growth, with tumor size smallest for mice homozygous for the human apoA1 transgene (hA-I Tg+/+), intermediate tumor size in mice heterozygous for the human apoA1 transgene (hA-I Tg+/-, referred to hereon as simply apoA1 transgenic (A-I Tg)), and largest tumor size in apoA1 null mice (A-I KO; Zamanian-Daryoush et al., 2013). The gene discussed is APOA1; the disease is neoplasm.