Unlike the observations with apoA-I/HDL peptide mimetics, which appear to inhibit tumor growth by squelching/decreasing circulating levels of the bioactive tumor promoting lipid LPA; the plasma level of LPA, was found to be similar in B16F10L melanoma tumor-bearing A-I KO vs. A-I Tg animals (Zamanian-Daryoush et al., 2013), thus eliminating titration of this bioactive lipid as a functional mechanism, in this setting, for apoA-I protein (Zamanian-Daryoush et al., 2013). This evidence concerns the gene APOA1 and melanoma.