Anti-tumor effects of apoA-I/HDL could be related to (i) the ability of apoA-I/HDL to modulate cholesterol content in immune or tumor cell membrane lipid rafts thus influencing signaling pathways, (ii) the lipid rafts’ role as a platform for biologically active lipids and proteins that may impact the immune response, (iii) the cross-talk between the tumor and surrounding stromal cells. Here, APOA1 is linked to neoplasm.