Furthermore, overall tumor burden and metastasis was strongly suppressed in response to challenge with the aggressive and metastatic syngeneic melanoma cells (B16F10L) in animals expressing the apoA1 transgene relative to apoA1 null or wild-type (WT) animals, culminating in improved overall survival (Zamanian-Daryoush et al., 2013). This evidence concerns the gene APOA1 and neoplasm.