The mimetics significantly decreased LPA-induced vascular endothelial growth factor (VEGF) production by cancer cells through inhibition of hypoxia-inducible factor-1α (HIF-1α) as well as interfering with VEGF-induced signaling in endothelial cells thus mitigating VEGF’s ability to promote angiogenesis (Gao et al., 2011, 2012). This evidence concerns the gene VEGFA and cancer.