Consequently, due to their anti-inflammatory activity and increased lipid binding properties apoA-I/HDL mimetics, when tested for anti-tumor activity, were shown to have protective activity in multiple mouse tumor models including ovarian (Su et al., 2010; Gao et al., 2011, 2012; Ganapathy et al., 2012), and colon cancer (Su et al., 2012). This evidence concerns the gene APOA1 and malignant colon neoplasm.