ApoA-I/HDL mimetics have been successfully used in a number of mouse models of atherosclerosis (Garber et al., 2001; Navab et al., 2010; Getz and Reardon, 2011) and shown to have anti-inflammatory and anti-oxidant activities as well as the ability to promote RCT (D’Souza et al., 2010; Ditiatkovski et al., 2013). Here, APOA1 is linked to atherosclerosis.