Thus, understanding the degree to which GR density and its sensitivity are altered could have direct implications on PTSD where GR sensitivity is dysregulated (Yehuda et al., 2004; Binder et al., 2008; Ising et al., 2008; Binder, 2009; Heim and Nemeroff, 2009). Here, NR3C1 is linked to post-traumatic stress disorder.