PDE6B and retinal degeneration: The rd1 mouse (Bowes et al., 1990) is probably the most prominent model for retinal degeneration in Retinitis Pigmentosa in humans—despite the fact that other than in the human condition, rd1 photoreceptor degeneration starts as early as postnatal day 10 (Paquet-Durand et al., 2011), and therefore degenerative processes likely interfere with retinal development.