Interestingly, superoxide dismutase-1 (SOD1) mutants that cause neurodegeneration in amyotrophic lateral sclerosis (ALS) have also been shown to inhibit ER-to-Golgi transport in neurons resulting in ER stress that can be ameliorated by over-expression of ER/Golgi vesicle machinery (Atkin et al., 2014). Here, SOD1 is linked to amyotrophic lateral sclerosis.