NUCB2 and major depressive disorder: It has been reported that the plasma nesfatin-1 level is statistically higher in patients with major depressive disorder (Ari et al., 2011) and associated with the elevated scores of anxiety and depression (Ari et al., 2011; Hofmann et al., 2013), and intracerebroventricular (ICV) injection of nesfatin-1 could induce anxiety- and fear-related behaviors (Merali et al., 2008).