APC and colorectal carcinoma: In an effort to better understand the biologic hallmarks of the disease, CRC has undergone extensive molecular characterization in recent years, which revealed important oncogenes (e.g., KRAS, BRAF, PIK3CA), tumor suppressor genes (e.g., APC, TP53, PTEN) and signaling pathways that are critical for the development, survival, and progression of CRC cells.