TGFB1 and helminthiasis: Interestingly, mice in which T cells express a dominant negative TGF-βRII are not more resistant to helminth infection, but show marked overexpression of inflammatory cytokines such as IFN-γ, blocking an effective type 2 anti-parasite response [71], [72]; in parallel, induction of IL-10 is abrogated in infected mice lacking T cell TGF-β signaling, emphasizing the importance of TGF-β in driving other pathways of immunosuppression [71].