NUPR1 and adenoma: In this experiments, Nupr1+/+ developed a significant number of adenomas grade 1 and 2 (29.1 ± 11.3 and 6.5 ± 2.3 per slice) while Nupr1–/– mice developed fewer lesions (1.5 ± 1.0 and 0.1 ± 0.1 lesions) (Fig. 5B,C).